The Rams' clearest advantage is the passing matchup against an Arizona defense with a much weaker model profile. Short throws to both sides stand out, and those areas represent meaningful shares of the Rams' offense. Matthew Stafford should have routes to sustain drives without needing every possession to produce a deep completion. Arizona's defensive EPA allowed is 0.193 per play against the Rams' 0.034, where lower is better.

Arizona's safety depth is a concern after Wydett Williams Jr. and Andrew Wingard missed Wednesday practice, while running back Jeremiyah Love was absent with an ankle injury. If Love remains unavailable, it could be harder to keep the Rams' offense off the field. Los Angeles has a significant absence of its own: Myles Garrett remains on injured reserve and will not have his practice window opened this week. That gives Jacoby Brissett some relief from the potential pass rush. No new injury adjustment is included. LA -12.5 at PointsBet (AU), priced at 1.90, is a PLAY with a 5.2-point edge. The large handicap still leaves little room for wasted possessions; the total is PASS.